Using the biotech station can cure any illness, but it can also create a deadly and highly contagious one...
Guinea Pig Disease
This disease was introduced in Livin' Large. Sims can catch it if they are bitten by a guinea pig that has a dirty cage, or from other Sims who have been infected with it. Objects cloned from the guinea pig can also cause this disease. Sims infected with it will sneeze and cough frequently, and their Comfort and Energy motives will decline. Infected Sims will die if not treated. There is a strange glitch that prevents Sim with GPD from being brought back to life, where they will die again if resurrected.
The action of a given instance of Guinea Pig Disease is restricted to a single lot, so a Sim who gets infected will not display symptoms, be infectious, or die outside of the lot he/she got infected on. A Sim with GPD can safely go to a community lot or be invited to another Sim's house as a visitor. It is possible for a Sim to be infected on multiple lots, however.
- Keep the sick Sim(s) home from work or school, and try to keep their Comfort and Energy motives up.
- Buy the Forgotten Guinea Pig painting. It will clear the disease from the household after 16 Sim hours.
- If the Sim is an adult, have them use The "Concoctanation Station" chemistry set. If a Sim uses it when the disease is present on the lot, there is a chance that he or she will make a white potion, which will cure the disease. Additionally, there is a good chance that the Sim will make a blue potion which will restore three random motives. While this will not directly cure the disease, anything that keeps a sick Sim's motives up will help them recover from it.
Also known as "Poopy Pants" (the name used by Maxis in the code), this disease was introduced in Vacation. It's a form of food poisoning, and Sims can get it from eating at buffet tables when their Hygiene is low. It will not kill a Sim, but is uncomfortable. Sims with this illness will have trouble keeping their Bladder meter full, and will spend plenty of time in the bathroom.
The disease is not deadly, and will go away on its own. Try to keep the affected Sim's Bladder motive up.
Introduced in Superstar, this is not a disease per se. It will occur if a famous Sim has repeated failures in Studio Town. The Sim will enter a catatonic state and lose Comfort, Fun, Bladder and Fame points. A mention of it will appear in the tabloid. 
Unleashed Mystery Illness
This was reportedly introduced in Unleashed. It was dubbed the "Mystery Illness" because its exact nature and origin was unknown. Its existence was inferred, but never officially acknowledged or confirmed, and reports of it spread around the Sims community. Reported symptoms are those of the Guinea Pig Disease, but it does not require the presence of a guinea pig. It could reportedly affect both humans and pets, and reported symptoms in pets include listlessness and an inability to maintain the Hunger motive.
It does not appear to exist as a separate entity, but may have been the result of a bug involving existing illnesses. What it is, and whether it exists at all, remains subject to dispute. Investigations by various hackers have discovered that there is no reference to disease in any of the files that come with Unleashed (see this thread at Simblesse Oblige), and that code which claims to cure the disease refers to a disease controller file which was included in Vacation, which actually contains code for Poopy Pants.
There have been rumors that a Sim who keeps operating the woodworking table in a room with no windows will get sick, or at least will develop a nasty cough; however, this has never been confirmed. An inspection of the crafting bench's file shows that there is no code for disease in it.
The Sims 2
- Coughing – Causes a drop in comfort.
- Sneezing – Causes a drop in comfort.
- Nausea – Causes a drop in comfort.
- Vomiting – Causes a drop in comfort. Affected Sim will run to a toilet, or vomit on the floor if they can't find one.
- Diarrhea – Causes a drop in bladder.
- Fatigue – Causes a drop in energy.
Food poisoning and morning sickness cannot be passed between Sims. All other diseases can, to varying degrees. Mysterious disease is more contagious than flu, which is more contagious than a cold, which is more contagious than pneumonia.
If certain illnesses are not cured within ten days, the Sim will die from illness. Children are taken away by a Social Worker before they get a chance to die. Toddlers and babies cannot get ill. The mysterious disease can kill a Sim of any age group in less than 24 Sim hours, so it's possible for a child to die of the mysterious disease.[confirmation needed]
Call in sick
This interaction is available by calling work on the phone, and allows a Sim to miss work without fear of being fired. It becomes available one hour before the carpool arrives, and remains available until the Sim is one hour late. If the Sim is not actually sick, its success depends on job performance. It will always succeed if the Sim is actually ill.
List of Illnesses
- Symptoms – Vomiting, Nausea
- Fatal? – No
- Contagious – No
Morning sickness almost always happens when a Sim is pregnant and in the first trimester. It also has the same symptoms as food poisoning. If the Sim is a female and she didn't plan for a baby, or if it's a male Sim and he wasn't recently abducted, then it is most likely he/she just ate some spoiled food.
The only way guaranteed to prevent a Sim from getting morning sickness is to download a mod that will stop it from happening. Otherwise its intensity varies from Sim to Sim.
- Symptoms – Vomiting, Nausea
- Fatal? – No
- Contagious – No
There is a 5% chance any time a Sim eats spoiled or burned food that the Sim will get food poisoning. This can occur if food spoils while a Sim is eating it, or if sloppy Sims eat out of the rubbish bin.
- Symptoms – Coughing, Sneezing
- Fatal? – No, but will become pneumonia if not cured within ten days
- Contagious – Highly
There is a 1% chance any time a Sim goes to work or school that the Sim will catch a cold. Infected Sims will suffer from coughing and sneezing fits, causing drops in comfort.
- Symptoms – Coughing, Fatigue
- Fatal? – Yes
- Contagious – Slightly
If the cold is not cured within ten days it will turn into pneumonia. The pneumonia has all the symptoms of both the cold and the flu[confirmation needed], as well as sharp and sudden drops in Energy in which a Sim appears to nearly pass out. If energy drops low enough, the Sim will pass out. Sims with pneumonia may die if not treated.
- Symptoms – Coughing, Diarrhea
- Fatal? – Yes
- Contagious – Highly
If a Sim goes near cockroaches, there is a 5% chance they will catch the flu. The flu has all the symptoms of a cold with sharp drops in fun and energy as well[confirmation needed]. Evil witches are immune to the disease spread by cockroaches.
When the Beaker household in Strangetown is first played , there will be cockroaches near the refrigerator. Both Loki and Nervous will go to stomp on them and are likely to catch the flu. It is best to cancel out this action before they get there, and call an exterminator.
- Symptoms – Two random symptoms.
- Fatal? – Yes
- Contagious – Extremely
Also known as "Virus", Sims can be infected with this when using the biotech station with low logic skill. It should be noted that this disease is highly contagious and can easily spread through the entire neighborhood in a matter of days.
The best cure for all illnesses is rest. Keep the sick Sim away from healthy Sims, and keep their comfort and energy up by making them sleep and relax on the bed, until a message appears saying they are cured. If the Sim is able to meditate, this will also help.
The medicine made with the biotech station cuts down the resting time needed to be cured of a sickness. Players who do not have either FreeTime (with up-to-date patches) or Apartment Life will need to get a mod from More Awesome Than You! for the medicine to work properly.
Grandma's Comfort Soup
With The Sims 2: FreeTime installed, Sims with Family as their primary or secondary aspiration can achieve the aspiration benefit Grandma's Comfort Soup. When eaten, it will cure any disease a Sim has. It is recommended to have at least one Family Sim in the household just in case any Sim has caught any illness. Sims can also add Grandma's Comfort Soup to the menu in an owned restaurant so they can cure any customers that happen to be ill. The chef doesn't need to have this aspiration benefit though.
The Sims 3
Nausea is a common illness Sims could have. Sims will get the "Nauseous" moodlet that will last for 2 hours, and after the moodlet expires, the Sims will throw up. Being nauseous isn't contagious nor fatal, and will go away after they vomit. Below is several ways to get nauseous.
- Morning Sickness
- Morning sickness will always happen when a Sim is pregnant and in the first trimester. Sims will randomly get the "Nauseous" moodlet and eventually they will vomit.
- Food Poisoning
- If Sims eat spoiled or burned food there is a slight chance they will receive the "Nauseous" moodlet.
- Visceroidal Nausea/Tiberium Poisoning
- Keeping Tiberium, a radioactive rock, in a Sim's inventory for a while will give them "Visceroidal Nausea" moodlet, which is similar to the normal "Nauseous" moodlet.
- Eating Meat
- If a Vegetarian eats meat, they will receive the Nauseous moodlet and will vomit after a while. It also happens to Vegetarian vampires who drink from Sims.
- Consuming Plasma
- When a normal Sim drinks Plasma or eats any products containing plasma, such as nectar, they will become Nauseous.
- Floor Hygienator Temporary Malfunction
- When a floor hygienator isn't created by Sims that have completed the Master Inventor skill challenge, it will have a temporary malfunction that causes it to backfire to the Sims, causing them to get nauseous.
- Experimental Treatment
- Sims who work in Medical career can try an experimental treatment on themselves or other Sims. One of the possible outcome of the treatment will cause Sims to pass out or get nauseous.
- Alchemy Failure
- While attempting to mix an alchemical elixir, a Sim may occasionally fail and receive the Nauseous moodlet instead.
- Herb Nausea
- Consuming or burning herbs can sometimes cause Sims to get nauseous and make them vomit.
As stated before, eating spoiled or burnt food may cause Sims to get nauseous. There's a 15% chance that eating from a food truck will give Sims the "Food Poisoning" moodlet. Snob Sims have 30% chance of getting food poisoning from the food truck.
If a Sim loses a fight with a Mummy, there's a chance they will get cursed. If the curse is not cured after two weeks, the Sim will die. Sims must go to the Sphinx and make a plea to enter the tomb inside the Sphinx. Then they have to explore to end of the tomb to get blessed with a Soulpeace Statue. The curse can also be cured by being kissed by a King Cobra (from the snake-charming basket).
In The Sims 3: Supernatural, if a Sim is cursed with the Pestilence Curse by a witch and is not cured within 24 hours, they can get sick. It can be cured by casting a Sunlight Charm on the cursed Sim.
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In The Sims 3: Seasons, Sims can get colds, more likely in Fall. Players will be notified when their Sims get a cold. Sims who get a cold will have "Germy" moodlet that will last for 2 days. The Cold is contagious, so it is best to keep sick Sims away from healthy Sims. Sims can get health advice at the hospital or get a flu shot that will make them immune for a full-year for §200 each. The flu shot is only available in Fall.
In The Sims 3: Seasons, Sims can get allergies from wildflowers, more likely in Spring. Sims get "Allergy Haze" moodlet when they get allergies, which lasts for up to 10 days. They can get an allergy shot at the hospital for §200. The allergy shot is only available in Spring. Allergies are genetic, and they may be passed down to the offspring.
The Sims Medieval
Unlike The Sims 3, The Sims Medieval offers both injury and disease. Death by plague is also present. Diseases will usually give Sims a bad moodlet and can be cured by visiting a Physician or by applying curative tonics and/or health salves. Every disease is contagious in this game.
This is the first and the least serious form of a disease. It can easily be cured by applying Weak Curative Tonics, or by visiting a Physician. Gives a -10 moodlet.
If a sickness is not cured, then it will turn into an infection. Infections are usually cured by applying Moderate Curative Tonics (unlocked by Quest) or by visiting a Physician. Gives a -20 moodlet.
An infection will turn into a disease if cure is not met. This kind of disease is quite serious. It can easily be cured by applying Strong Curative Tonics or visiting a Physician. Gives a -30 moodlet.
In case a disease is not cured, it will turn into a plague. Plague can cause a Sim to die, so it has to be cured immediately. When a Sim has a plague, black smoke will appear above their head. A Plague can only be cured by visiting a Physician. It can also be reduced to an illness by a Wizard, using the spell Miasma. Mend will also completely remove it after using the spell Miasma to reduce it. Gives a -50 moodlet.
This is the least serious form of injury. It can easily be healed either by applying Weak Health Salves or visiting a Physician. Gives a -10 moodlet.
When a minor injury is not healed, it will turn into a moderate injury. Moderate injuries can be healed by applying Moderate Health Salves (unlocked by Quest) or visiting a Physician. Gives a -20 moodlet.
The most serious form of injury. The Sim will be in bandages. It can easily be healed by applying Strong Health Salves or visiting a Physician. Gives a -30 moodlet.